EgyptAir flight 804 heading from Paris to Cairo disappears from radar with 66 people on board, the airline reports.
EgyptAir flight 804 travelling from Paris to Cairo has disappeared from radar with 56 passengers and 10 crew members on board, the airline has said.
French President Francois Hollande said in a televised address that the plane had crashed early on Thursday.
The plane made "sudden swerves" mid-air and plunged before dropping off radars in the southern Mediterranean, Greece's defence minister said.
"At 3:39am the course of the aircraft was south and south-east of Kassos and Karpathos [islands] ... immediately after it entered Cairo FIR and made swerves and a descent I describe; 90 degrees left and then 360 degrees to the right," Defence Minister Panos Kammenos told a news conference.
Greek authorities mounted a search in the area south of the island of Karpathos without result so far, he said.
However, Egypt's civil aviation ministry said in a statement it was too early to confirm if the passenger plane had crashed.
According to EgyptAir, the plane took off from Paris' Charles De Gaulle Airport shortly after 11pm local time.
"At 4:26am, rescue teams affiliated with the Egyptian armed forces have received an SOS message from the emergency unit of the missing plane," the airline said in a tweet. However, the Egyptian army later denied detecting a distress signal from the missing plane, according to AFP news agency.
The Airbus A320 was flying at 37,000 feet when it disappeared 16km after entering Egyptian air space, the airline said.