Megalyn Echikunwoke was born in Spokane, Washington to an Igbo Nigerian father and a Navajo Indian mother. She was a series regular on the sci-fi series The 4400, as the adult version of the mysterious Isabelle Tyler. Echikunwoke left the show in 2007. Echikunwoke has also been seen in the MTV soap opera, Spyder Games, as Cherish Pardee, a coffee house singer and in Like Family as Danika. She also has a recurring role in the first season of 24 as David Palmer's daughter, Nicole. In season 7 of CSI: Miami, Echikunwoke joined the cast as the new Medical Examiner, Dr. Tara Price. She appeared on the show for one season.
Echikunwoke landed a recurring role in at least three episodes of TNT's Raising the Bar in June 2009. She played the love interest of attorney Marcus McGrath, played by J. August Richards. In 2011, Echikunwoke played Holly in the fourth season of 90210.